Pharmacogenomic responses of rat liver to methylprednisolone: An approach to mining a rich microarray time series. Male and female diestrous 1 rats were injected with endotoxin Escherichia coli LPS B4; Sigma as a model of systemic inflammatory response.
Copyright notice. May 4, Our experiments also defined specific genes with altered expression in response to glucocorticoid treatment in both sexes, but in opposite directions.
Concept 9: Specialized chromosomes determine gender. Thus, glucocorticoids regulate significantly more genes implicated in inflammatory disorders in livers from male rats than in those from female animals. One possible explanation is the presence of gender-specific profiles of co-regulatory molecules that contribute to the function of nuclear hormone receptors and other transcription factors.
Biography 7: Walther Flemming InWalther Flemming published the definitive study of the cellular process of mitosis. Sex-specific early growth hormone response genes in rat liver. Signature pattern extraction The extraction of gene expression patterns in male and female glucocorticoid-regulated genes through EPIG was performed in the data set generated by microarray analysis.
See also X trisomy ; XYY-trisomy. The X chromosome is always present as the 23rd chromosome in the ovum, while either an X or a Y chromosome can be present in an individual sperm. Scientists looking at cells under the microscope first observed chromosomes in the late s. However, heteromorphic sex chromosomes are relatively rare, with only 5 species known as of
Analyses of gender-specific expression patterns of nuclear receptor co-regulators. Sexual dimorphism of rat liver gene expression: Regulatory role of growth hormone revealed by deoxyribonucleic acid microarray analysis.
N Engl J Med.